Yes, you can leave a Maltese home alone. An adult Maltese can be left alone for 8 hours at home given you provide it with enough food and water. However, this is not ideal for a Maltese. Whether they’re puppies or adults, they develop separation anxiety easily.
A Maltese puppy under 6 months old should only be left alone for a few hours. They will become stressed and upset with the lack of contact which causes them to behave badly. You should have someone like a friend or a dog sitter visit the house while you’re out.
Furthermore, if you can provide your Maltese with some exercise before you head out, your Maltese will be less inclined to become stressed and destroy furniture or develop separation anxiety. They will want to nap and relax after a good work out session.